CRISPR approach turns oncogene amplification into a weakness in multiple solid tumors

CRISPR approach turns oncogene amplification into a weakness in multiple solid tumors

The onset and aggressiveness of cancer are related to the abnormal behavior of certain genes, known as oncogenes. The best-known of these alterations is mutation, but it is not the only one. Sometimes, within a cell, a very high number of copies of the oncogene appear—tens or even hundreds. This amplification of oncogenes occurs in a significant proportion of solid tumors and may make the tumor more aggressive and prevent the body's defenses fro…