Create a Large Database to Investigate Fungal Mutations Associated with Antimicrobial Resistance

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Resistance to antifungals is a growing threat to global health and has recently been incorporated into the list of health priorities of the World Health Organization (WHO). However, fungi have historically received less attention than bacteria in drug surveillance and development programs, despite their clinical impact and causing significant losses in agricultural crops. In fiction, works such as The Last of Us (HBO) have popularized the idea o…

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Antimicrobial resistance (RAM) is a global threat, especially in fungal pathogens; to optimize the use of available antifungals, researchers from the Higher Council for Scientific Research (CSIC) have created a large database and software to investigate fungal mutations associated with antimicrobial resistance.

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However, fungi have been left in the background against bacteria in drug surveillance and development programs, despite their clinical impact and causing significant losses in agriculture. Advances in massive DNA sequencing have opened up new avenues to investigate resistance to antifungal drugs, but the complexity of the genome of fungi and the absence of complete databases have hampered progress on a large scale. To overcome these challenges, …