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Could RNA Therapy Preserve Lean Muscle and Boost Fat Loss During GLP-1 Treatment?

The combination cut lean-mass loss to about 5.5%, compared with about 10% for semaglutide alone, while improving glucose tolerance in mice.

An experimental RNA therapy targeting fat-cell thermogenesis enhanced semaglutide-induced weight loss in mice while reducing lean-mass loss and improving metabolic health.

6 Articles

Lean Right

Some people suffer setbacks after using weight loss medication, losing muscle along with fat. Rapid muscle loss makes one more susceptible to illness and slows down recovery. Scientists have opened a path to prevent muscle loss by using a method that promotes fat burning simultaneously with the use of weight loss drugs. A research team led by Professor Joseph Bass of Northwestern University School of Medicine stated, “RNA therapy [is similar to]…

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Naiarabrocal Endocrinology In 'PNAS' GLP-1 drugs have transformed the treatment of obesity thanks to their ability to achieve significant weight reductions. However, part of this loss corresponds to lean mass and not just fat. In addition, after discontinuation of treatment, weight recovery can occur, mainly at the expense of fat tissue.A new preclinical study of researchers from Northwestern University, in the United States, explores a possible…

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Newsweek broke the news in New York, United States on Monday, September 21, 2026.
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