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Combined physical frailty and depression may sharply raise dementia risk

A study of 220,947 older adults found frailty increased dementia risk 2.5 times, depression 59%, and both conditions tripled the risk, accounting for 17% of cases.

Summary by News Medical
Concurrent physical frailty and depression likely boost the risk of dementia in older people, with the interaction of these 2 factors alone contributing around 17% of the overall risk, suggest the findings of a large international study, published in the open access journal General Psychiatry.

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scimex.org broke the news in on Tuesday, December 16, 2025.
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