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College Football Score Predictions: Best Bets, Picks for Week 1
College football's College Football Playoff race officially begins as Lane Kiffin debuts with a transfer-heavy LSU roster against Clemson in the weekend’s sole Top 25 showdown.
College football officially opens its season on Thursday, September 3, 2026, with a full schedule of Week 1 games as fans return for the race to the College Football Playoff.
Clemson faces LSU on Saturday at 7:30 p.m. ET, featuring two programs seeking to recapture former glory where coach Kiffin unveils a new roster and Dabo Swinney strengthens his defense via the transfer portal.
The only game featuring two Associated Press Top 25 teams pits Ole Miss against Louisville on Sunday at Nissan Stadium in Nashville, Tennessee, the marquee matchup of Week 1.
Analysts give Mississippi a 62% win probability against Louisville's 38%, while the Rebels enter as 6.5-point favorites according to BetMGM Sportsbook for the Sunday clash.
Oregon hosts Boise State on Saturday, a rematch of their 2024 meeting decided by a late field goal, with the Ducks entering as 24.5-point favorites despite the Broncos returning experienced playmakers.