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College Football Score Predictions: Best Bets, Picks for Week 1

College football's College Football Playoff race officially begins as Lane Kiffin debuts with a transfer-heavy LSU roster against Clemson in the weekend’s sole Top 25 showdown.

  • College football officially opens its season on Thursday, September 3, 2026, with a full schedule of Week 1 games as fans return for the race to the College Football Playoff.
  • Clemson faces LSU on Saturday at 7:30 p.m. ET, featuring two programs seeking to recapture former glory where coach Kiffin unveils a new roster and Dabo Swinney strengthens his defense via the transfer portal.
  • The only game featuring two Associated Press Top 25 teams pits Ole Miss against Louisville on Sunday at Nissan Stadium in Nashville, Tennessee, the marquee matchup of Week 1.
  • Analysts give Mississippi a 62% win probability against Louisville's 38%, while the Rebels enter as 6.5-point favorites according to BetMGM Sportsbook for the Sunday clash.
  • Oregon hosts Boise State on Saturday, a rematch of their 2024 meeting decided by a late field goal, with the Ducks entering as 24.5-point favorites despite the Broncos returning experienced playmakers.
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  • 64% of the sources are Center
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abc News broke the news in New York, United States on Tuesday, September 1, 2026.
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