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Real-World Study Finds Lower Weight Loss with GLP-1 Drugs Due to Early Discontinuation
- Researchers from Cleveland Clinic published a June 10, 2025 study showing semaglutide and tirzepatide caused smaller weight loss in adults treated for obesity in real-world U.S. settings.
- The differences from clinical trials were due to patients stopping their treatment more frequently and receiving reduced maintenance doses in routine clinical settings.
- Among 7,881 patients treated between 2021 and 2023, more than 20% discontinued their medication within the first three months and 32% stopped between three months and one year; those who remained on treatment for the full year experienced an average body weight reduction of 11.9%.
- Dr. Hamlet Gasoyan emphasized that insights gained from how these drugs are utilized in everyday clinical practice, along with the related patient outcomes, can guide healthcare providers and patients in making informed choices about when to stop treatment and how to manage maintenance dosing for effective weight loss.
- The study highlighted that treatment discontinuation also harmed blood sugar control in prediabetic patients, emphasizing the need for persistence to achieve clinical benefits.
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Real-world study finds lower weight loss with GLP-1 drugs due to early discontinuation
A Cleveland Clinic study shows that semaglutide and tirzepatide – injectable GLP-1 drugs for obesity – produce smaller weight loss in a real-world setting because patients discontinue treatment or use lower maintenance dosages.
·United States
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