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Ageing Is Linked to Inflammation — but only in the Industrialized World

  • On June 30, researchers reported high inflammation levels in two indigenous groups that do not increase with age, linking inflammation to industrialised lifestyles, not ageing.
  • Building on decades of ageing research, the study compared four populations—Italy, Singapore, the Tsimane, and Orang Asli—to assess how lifestyle influences inflammation beyond age-related effects.
  • Analysis of blood samples from 2,876 adults across four populations shows 19 cytokines linked to inflammation, with ageing patterns only in industrialized groups, challenging universal inflammaging theory.
  • The journal Nature Aging asserts that inflammaging is largely a byproduct of industrialised lifestyles, calling for holistic research on environment, culture, and lifestyle factors.
  • Researchers call for larger, diverse longitudinal studies and the development of standardized, context-aware tools to better understand how environmental factors influence inflammaging.
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17 Articles

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Left
4
Center
3
Right

Inflammation is increasing in this country in old age – and with them chronic diseases. But now a study shows that this is not the case everywhere.

·Munich, Germany
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People living in industrialized countries have a link between age-related diseases and chronic inflammation. However, this link does not appear to hold true among some indigenous peoples, an international study suggests.

·Estonia
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Lean Left

A new study shows that the same indicators of inflammation with age do not appear in non-industrialized populations, indicating the importance of lifestyles in ageing.

·Spain
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  • 57% of the sources lean Left
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Nature broke the news in United Kingdom on Monday, June 30, 2025.
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