A Hidden Loop Is Powering Deadly Pancreatic Cancer

A hidden loop is powering deadly pancreatic cancer

Pancreatic cancer is notoriously hard to treat, often resisting therapies that target its most common mutations. Researchers have now uncovered a hidden three-part loop that fuels tumor growth, involving the cancer drivers SRSF1, AURKA, and MYC. By targeting just one part of this loop with a specially designed molecule, they were able to shut down all three at once. The result was a dramatic loss of tumor cell survival, offering new hope for sma…

Circuit Driving Aggressive Pancreatic Cancer Targeted by Splice-Switching ASO

Researchers at Cold Spring Harbor Laboratory have developed a potential new therapeutic strategy for pancreatic ductal adenocarcinoma (PDAC) addressing a newly characterized circuit that promotes aggressive tumor growth. In their study, published in Molecular Cell, the Cold Spring team reported on the development of an antisense oligonucleotide (ASO) designed to disrupt alternative splicing of Aurora kinase A (AURKA), which essentially short cir…