Cigarette Smoke May Prime Lung Stem Cells for Different Types of Lung Cancer
Researchers found smoke-exposed lung stem cells formed distinct precancerous states, and only cells with KRAS or TP53 changes became tumors.
7 Articles
7 Articles
Cigarette smoke alters lung stem cells to drive specific cancers
Chronic exposure to cigarette smoke may reprogram different populations of lung stem cells, which maintain and repair lung tissue, in ways that make them vulnerable to specific cancer-causing gene alterations and ultimately helps determine the type of lung cancer that develops.
Medical Xpress
NewswiseCigarette smoke may prime lung stem cells for different types of lung cancer
Chronic exposure to cigarette smoke may reprogram different populations of lung stem cells, which maintain and repair lung tissue, in ways that make them vulnerable to specific cancer-causing gene alterations and ultimately help determine the type of lung cancer that develops.
AGI - Chronic exposure to cigarette smoke can prepare lung cells for the development of cancer even before genetic mutations typically associated with cancer occur. Smoking induces an epigenetic state that allows cells to evade the immune response and reduces the signals that normally lead to their death. This is what emerges from a study conducted by Na Wang, Stephen B. Baylin, Michelle Vaz and colleagues at Johns Hopkins University School of M…
Chronic contact with components of cigarette smoke can transfer lung stem cells epigenetically into different cancer-prone states. In organoids from mouse lunges, smoke exposure and typical cancer changes alone were not sufficient for tumors, but together. Depending on the genetic change, different forms of non-small cell lung cancer were created in the mouse model, while human organoids so far only confirm early cell changes. Baltimore (U.S.A.)…
Coverage Details
Bias Distribution
- 100% of the sources are Center
Factuality
To view factuality data please Upgrade to Premium
