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Better Control of Childhood EoE Inflammation Linked to Less Esophageal Stiffening
Study shows esophageal stiffness predicts disease complications and treatment response in pediatric eosinophilic esophagitis, aiding targeted therapy decisions for patients, researchers said.
- On August 15, 2025, researchers from Children's Hospital of Philadelphia and Children's Hospital Colorado published online in Gastroenterology that better control of EoE inflammation during childhood leads to less esophageal stiffening and fewer complications.
- Amanda Muir noted this is the first prospective study to follow pediatric EoE patients over time, with researchers tracking esophageal changes in 112 children aged 3 to 18 years old, some over 4 years.
- Using Endoluminal functional imaging , the researchers studied a cohort of pediatric EoE patients with follow-up durations varying, including some over 4 years.
- After adjusting for different factors, patients with lower esophageal distensibility had increased odds of dysphagia, and tissue samples showing response demonstrated the greatest improvement in distensibility.
- Beyond this study, the authors suggest molecular-level studies could pinpoint high-risk patients and esophageal stiffness may guide therapy benefits, as the study found these biomarkers indicate disease progression.
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Better control of childhood EoE inflammation linked to less esophageal stiffening
Researchers from Children's Hospital of Philadelphia (CHOP) and Children's Hospital Colorado have found that better control of chronic eosinophilic esophagitis (EoE)-associated inflammation during childhood leads to less stiffening of the esophagus, resulting in fewer disease complications. Using Endoluminal functional imaging (FLIP), the study team suggests this could be a key marker for assessing disease severity and progression. The findings …
Fox 59 Indianapolis+23 Reposted by 23 other sources
Children's Hospital of Philadelphia and Children's Hospital Colorado Researchers Conduct First Prospective Study of Pediatric EoE Patients and Disease Progression
·Indianapolis, United States
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