Childhood Chemotherapy Leaves Lasting DNA Damage in Healthy Tissues

Childhood Chemotherapy Leaves Lasting DNA Damage in Healthy Tissues

Certain chemotherapy drugs can age children’s healthy cells, with some children showing levels of genetic damage comparable to those found in adult tissues.

Platinum-based chemotherapy in childhood causes mutations that age the liver

Platinum chemotherapy aged the liver cells of treated children, making them look more like adult liver cells and possibly raising the long-term risk of new tumors