Characterization of a Two-Component Kinase That Initiates the Bacterial Catabolism of Hydroxyphenylethanones - Science in Vancouver

Characterization of a Two-Component Kinase That Initiates the Bacterial Catabolism of Hydroxyphenylethanones - Science in Vancouver

The prodigious ability of bacteria to catabolize aromatic compounds has sparked considerable efforts to engineer bacteria to valorize lignin, an under-utilized component of biomass. Despite decades of study, key catabolic pathways and enzymes remain poorly characterized. We recently identified the hydroxyphenylethanone (Hpe) pathway, which enables Rhodococcus rhodochrous GD02 and other bacteria to catabolize 4-hydroxyacetophenone (HAP) and aceto…