Chain Reaction that Begins when Tumor Suppression Gene Is Switched Off Offers Clues to How Cancer Develops
4 Articles
4 Articles
Chain reaction that begins when tumor suppression gene is switched off offers clues to how cancer develops
A tumor suppressor gene known as p53 is mutated in more than half of all cancers, but how it acts to prevent cancer formation is largely unknown. A study by UT Southwestern Medical Center researchers sheds light on this phenomenon by showing what happens when p53 becomes disabled, revealing the gene's diverse roles in maintaining healthy metabolic activity, repressing mobile genes called retrotransposons and preventing cells from adopting featur…
What Happens When a Key Cancer Defense Fails?
A tumor suppressor gene known as p53 is mutated in more than half of all cancers, but how it acts to prevent cancer formation is largely unknown. A study by UT Southwestern Medical Center researchers sheds light on this phenomenon by showing what happens when p53 becomes disabled, revealing the gene's diverse roles in maintaining healthy metabolic activity, repressing mobile genes called retrotransposons, and preventing cells from adopting featu…
The scientific investigation of the p53 mutation shows how structural changes subvert strict biological control. This phenomenon demonstrates the snoring expansion of defective units long before the effective formation of any tumor mass in the body. How does cell expansion occur in normal tissues? Laboratory analyses indicate that the absence of a suppressor gene...
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