Catalytic Enantioselective -Wittig Rearrangement Breakthrough

Catalytic Enantioselective -Wittig Rearrangement Breakthrough

In a groundbreaking development poised to reshape synthetic organic chemistry, researchers have unveiled a novel catalytic cascade that achieves an enantioselective [1,2]-Wittig rearrangement of allylic ethers with unprecedented precision. This method, facilitated by a chiral tert-butyl-BIMP catalyst, provides access to enantioenriched homoallylic tertiary alcohols, compounds of significant value for pharmaceutical and fine chemical synthesis, a…