Cannabidiol Prevents Cognitive and Social Deficits in a Male Rat Model of Alzheimer’s Disease Through CB1 Activation and Inflammation Modulation

Cannabidiol prevents cognitive and social deficits in a male rat model of Alzheimer’s disease through CB1 activation and inflammation modulation

Cognitive decline is a hallmark of Alzheimer’s disease (AD). Cannabidiol (CBD), a non-intoxicating phytocannabinoid with immunomodulatory properties, shows promise in alleviating AD symptoms. This study examined the effects of chronic CBD treatment in a male rat model of sporadic AD induced by intracerebroventricular streptozotocin (ICV-STZ) and explored its impact on neuroinflammatory genes and cannabinoid signaling. STZ rats showed impaired pe…

Cannabidiol prevents Alzheimer's-like cognitive decline in new rat study

A compound found in cannabis may help protect the brain from early memory and social problems linked to Alzheimer’s disease. A new animal study published in Neuropsychopharmacology found that cannabidiol prevented cognitive decline in rats by reducing brain inflammation and activating key brain receptors. Alzheimer’s disease is a progressive brain disorder best known for causing memory loss, but it also affects thinking, decision-making, and soc…