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Nanobody Therapy Rescues Behavioural Deficits of NMDA Receptor Hypofunction

Summary by Nature
There is an urgent need for efficient and innovative therapies to treat brain disorders such as psychiatric and neurodegenerative diseases. Immunotherapies have proved to be efficient in many medical areas, but have not been considered to treat brain diseases due to the poor brain penetration of immunoglobulins1,2. Here we developed a bivalent biparatopic antibody, made of two camelid heavy-chain antibodies (called nanobodies)3, one binding to, …

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A team of French researchers found that camelidae antibody drifts could affect the brain, and thus treat certain mental disorders.

·Paris, France
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The lamas could soon advance the research for treatments for schizophrenia, reveals a study this Wednesday, July 23. French researchers have shown that this animal produces antibodies that are more powerful than those currently used. Tests still have to be carried out before this hope becomes a reality. - Schizophrenia: the hope of a new treatment based on... llama antibodies (Health and well-being).

The lamas have a particular type of antibodies from which scientists have just produced mini-antibodies. These "nanocorps" easily cross the biological barrier that protects brain cells, making them more effective than the antibodies used until then in treatments. Biodegradable and associated with limited side effects, they now represent the promise of a new generation of treatments for schizophrenia. These results, carried by scientists from the…

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Nature broke the news in United Kingdom on Wednesday, July 23, 2025.
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