Cancer-related DNA changes may appear in blood years before diagnosis
Researchers found blood methylation signals that identified future prostate cancer with 3.55-fold higher risk and outperformed breast cancer prediction.
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One study found epigenetic changes in blood samples taken years before prostate or breast tumors appeared; scientists still try to explain what these signs represent.
Cancer-related DNA changes may appear in blood years before diagnosis
Researchers found that genome-wide plasma cfDNA methylation profiles collected before diagnosis contained early molecular signatures associated with future prostate and breast cancer, with prostate silencer methylation providing the stronger risk stratification. Breast enhancer signals were weaker and varied by subtype and disease stage, indicating that cfDNA methylation may have greater value for risk assessment and surveillance than as a stand…
Researchers at Oxford and Toronto have found chemical changes in the DNA of blood that could identify people at high risk of prostate cancer five to eight years before diagnosis. For breast cancer, the signal was much weaker, and none of the results are yet a test that can be used in healthcare. The study was published in the scientific journal Cell Genomics. It is led by researchers at Oxford Population Health and the University of Toronto, and…
Predict Cancer Years Early: How Blood DNA Tests Signal Risk - Archyworldys
Liquid biopsies and DNA methylation analysis are transforming early cancer detection, with recent research published in Cell Genomics showing that blood samples collected up to nine years before a diagnosis capture early biological responses to cancer development. Globally, cancer remains the second leading cause of death, largely because late diagnoses hinder successful treatment. DNA Methylation ...
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