A new study from researchers at The University of Texas MD Anderson Cancer Center finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods.

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Normal breast tissue cells harbor cancer-like genetic abnormalities

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Ian Birkby

By Nancy Lapid (Reuters) –     Healthy women’s breasts contain small numbers of cells with genetic changes characteristic of invasive breast cancer, two separate papers reported on Wednesday, potentially increasing the risk of incorrect diagnoses. With molecular diagnostic tools being developed to detect cancer at earlier stages, the presence of cells with aneuploidy – a gain or loss of chromosomes – also raises questions about what is normal, t…

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Midwest Communications

Health Rounds: Features of cancer found in healthy breast cells

Researchers have pinpointed what could be the early genetic origins of breast cancer -- cancer-like mutations appearing in the cells of healthy women. In a new study, the international collaborators analyzed the genomes of more than 48,000 individual breast cells from women without cancer, using novel techniques for decoding the genes of single cells. While the vast majority of cells appeared normal, nearly all of the women harbored a small numb…

Science Daily

Daniel Hogan

Cancer-like mutations in healthy cells point to origins of breast cancer

News-Medical.net

Chromosome Abnormalities Found in Healthy Women’s Breast Cells

Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School, and Memorial Sloan Kettering Cancer Center (MSK) have identified early genetic alterations in healthy women’s breast cells that could be among the first steps leading to breast cancer. The findings, published today in Nature Genetics, suggest that cancer-like mutations appear silently in breast cells that appear normal, potentially offering insights into …

Inside Precision Medicine

Cancer-Like Genetic Mutations Found in Healthy Breast Tissue Cells

Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of breast cancer—cancer-like mutations appearing in the cells of healthy women. In a new study, the international collaborators analyzed the genomes of more than 48,000 individual breast cells from women without cancer, using novel techniques for decodi…

lifesciencesbc.ca

Cancer-like Mutations in Healthy Cells Point to Origins of Breast Cancer - Life Sciences British Columbia

Breast tissue contains normal cells with genetic changes found in invasive breast cancers, which may guide future approaches to early detection

Normal breast tissue cells harbor cancer-like genetic abnormalities

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