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Genetically Modified Herpes Virus Shows Promise Against Advanced Melanoma
LOS ANGELES COUNTY, CALIFORNIA, JUL 08 – The engineered herpes virus RP1 combined with nivolumab caused tumor shrinkage or disappearance in one-third of advanced melanoma patients in phase 1-2 trials, FDA review pending.
- At the ASCO meeting in 2025, one-third of advanced melanoma patients treated with RP1 plus nivolumab saw tumor shrinkage, with nearly one-sixth experiencing complete responses.
- Driven by the need for better treatments, the IGNYTE trial involved 140 patients with resistant advanced melanoma, which has a median survival of only a few years.
- Published phase 1-2 data show RP1, combined with nivolumab, reduces tumors beyond injection sites, with results presented at ASCO and published in the Journal of Clinical Oncology, prompting optimism from Dr. In.
- Following the FDA's January 2025 priority review, the phase 3 IGNYTE-3 trial with over 400 participants is now open, advancing RP1's regulatory path.
- Beyond injected tumors, experts predict RP1 will see broader use than T-VEC, the only oncolytic virus approved so far, potentially revolutionizing cancer immunotherapy.
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18 Articles
18 Articles
Genetically modified herpes virus shows promise against advanced melanoma
The herpes simplex virus type 1 (HSV-1), which affects almost two-thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.
·United States
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Medical XpressReposted by 
University of Southern California
University of Southern CaliforniaCancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma
The herpes simplex virus type 1 (HSV-1), which affects almost two‑thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.
NewScientistReposted by 
Anti-Aging, Acupuncture and Health News
Anti-Aging, Acupuncture and Health NewsHerpes virus could soon be approved to treat severe skin cancer
A cancer-killing virus could soon be approved for use after shrinking tumours in a third of people with late-stage melanoma
·Baltimore, United States
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Total News Sources18
Leaning Left2Leaning Right0Center5Last UpdatedBias Distribution71% Center
Bias Distribution
- 71% of the sources are Center
71% Center
L 29%
C 71%
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