Cancer evolution could inform targets for personalized anticancer vaccines

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Cancer evolution could inform targets for personalized anticancer vaccines

Through comprehensive genomic and immune analyses, mechanisms of lung cancer resistance after treatment with EGFR inhibition and vaccine therapy were investigated. This case report, together with data from the longitudinal lung cancer study TRACERx, highlight the importance of understanding when targeted variants are acquired during the cancer’s evolutionary history. Treatment-resistance mechanisms identified through longitudinal analysis of can…