Circadian Clock Disruption in Parkinson’s: Causes and Therapies

Circadian Clock Disruption in Parkinson’s: Causes and Therapies

In recent years, the intricate relationship between the circadian clock and neurodegenerative diseases has emerged as a critical area of investigation, revealing profound implications for understanding and treating Parkinson’s disease. The circadian clock, an internal timekeeping system that regulates physiological and behavioral rhythms over approximately 24 hours, influences numerous biological processes including sleep-wake cycles, hormone se…

Canada considers approval of Parkinson's therapy Crexont

Health Canada will review Knight Therapeutics’ application seeking approval of Crexont, an extended-release formulation of levodopa and carbidopa aimed at providing steady symptom control in Parkinson’s disease, the company said. The Parkinson’s therapy is designed to maintain consistent levels of levodopa and carbidopa in the body, prolonging periods of optimal symptom control — known as good on time — with fewer daily doses. Knight plans to su…