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California officials confirm 1st US case of severe mpox strain with no travel history

The first U.S. case of locally transmitted Clade I mpox, a more severe strain, was confirmed in Long Beach, with only eight national cases reported, officials said.

  • Long Beach health officials are investigating a resident's infection with clade I mpox, the first known case in the U.S. without a travel history.
  • The unidentified patient is now recovering at home after hospitalization and is the seventh person nationwide confirmed with clade I mpox.
  • Health officials state that clade I mpox generally causes more severe illness than clade II, which was involved in a 2022-23 outbreak.
  • Despite the low risk, vaccines are recommended for certain groups, according to Mayor Rex Richardson's statement emphasizing the need for vigilance and continued community surveillance.
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It is characterized by rash or skin lesions that usually concentrate on the face and palms of the hands and feet

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MyNewsLA.com broke the news in on Thursday, October 16, 2025.
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