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Brain Organoids Map How Distinct Autism Mutations Converge in Early Development
UCLA and Stanford teams found eight autism-linked mutations converge on pathways like neuronal maturation and synapse formation, analyzed in 70 stem cell lines, study shows.
Organoids have helped create a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development. This work provides new insights into the ways diverse genetic causes may lead to shared features and symptoms of the disorder. Over the past two decades, more than 100 genes harboring rare mutations linked to autism have been identified. This genetic heterogeneity has raised a fun…
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2 Articles
Brain Organoids Map How Distinct Autism Mutations Converge in Early Development
Organoids have helped create a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development. This work provides new insights into the ways diverse genetic causes may lead to shared features and symptoms of the disorder. Over the past two decades, more than 100 genes harboring rare mutations linked to autism have been identified. This genetic heterogeneity has raised a fun…
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