Brain enzyme caught doing something unexpected—it builds polysialic acid on itself
2 Articles
2 Articles
Brain enzyme caught doing something unexpected—it builds polysialic acid on itself
A chance discovery at Nagoya University in Japan has shown that a well-known brain enzyme has a hidden ability: It builds a sugar chain on itself, becomes secreted from the cell and deactivates, then switches on outside the cell once the chain is removed. The finding, published in the Journal of Biological Chemistry, overturns a decades-old assumption about how polysialic acid, a sugar chain critical for brain development and function, is produc…
An accidental discovery at Nagoya University in Japan showed that a well-known brain enzyme has a hidden capacity: it builds a sugar chain on itself, is secreted by the cell and deactivates, then activates outside the cell once the chain is removed. The discovery, published in the Journal [...]
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