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Fatty Liver Disease Risk Linked to Both Sugary and Diet Drinks

A study of 123,788 UK Biobank participants found sugary drinks raise fatty liver risk by 50% and artificially sweetened drinks by 60%, with water lowering risk.

  • On Oct. 7, 2025, researchers reported both sugary and artificially sweetened drinks were linked to higher MASLD risk using nearly 124,000 UK Biobank participants.
  • MASLD, a widespread disease, involves fat buildup in the liver and affects more than 30% of people worldwide, with sugary beverages linked to blood sugar spikes, weight gain, and uric acid increases, while artificially sweetened beverages may alter the gut microbiome and insulin, Lihe Liu said.
  • During a median 10-year follow-up, nearly 1,200 participants developed MASLD and 108 died from liver-related causes.
  • Replacing sugary beverages with water reduced risk by nearly 13%, while drinking water instead of artificially sweetened drinks lowered fatty liver disease risk by more than 15%. Researchers advised limiting both drink types and said water remains the best choice.
  • Findings presented at medical meetings remain preliminary until peer review, and the study team plans long-term clinical trials to explore why artificially sweetened drinks increase liver-related mortality.
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Floyd Chronicle & Times broke the news in Prestonsburg, United States on Tuesday, October 7, 2025.
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