Boosting OXPHOS Prevents Moyamoya-like Lesions in Mice

OxPhos System Evolution Explored, Indicating Links Between Mutations and Disease

Mitochondria are known as the body’s “energy factories,” and their function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system represents the main site of metabolic and energy integration in the cell and acts like a biochemical assembly line, transforming oxygen and nutrients into usable energy. Research headed by scientists at GENOXPHOS group at the Spanish National Centre for Car…

Boosting OXPHOS Prevents Moyamoya-like Lesions in Mice

In a groundbreaking study published in Nature Communications, researchers have unveiled new mechanistic insights into the pathogenesis of moyamoya-like cerebrovascular lesions by investigating the role of immature smooth muscle cells harboring a specific ACTA2 mutation. The study centers on the Acta2^R179C/+ mutation in smooth muscle cells (SMCs) and demonstrates how this genetic alteration precipitates vascular […]