US EditionNew Blood Tests Achieve Breakthrough in Alzheimer's Detection and Monitoring
- On March 31, 2025, researchers from Washington University School of Medicine and Lund University in Sweden published a study in Nature Medicine detailing the development of a new blood test for Alzheimer's disease that indicates the stage and severity of the disease.
- While several blood tests already exist to aid in diagnosing Alzheimer's in individuals with cognitive symptoms by detecting amyloid plaques, they do not indicate the clinical stage or severity of the disease, unlike this new test.
- The new blood test measures levels of MTBR-tau243, which researchers found correlate with the amount of toxic tau aggregates in the brain, reflecting the severity and stage of Alzheimer's with 92% accuracy, and allowing them to distinguish between early and late stages of the disease, as well as other conditions causing cognitive symptoms.
- According to Dr. Randall J. Bateman of WashU Medicine and Dr. Oskar Hansson of Lund University, this new, more accessible blood test, which measures MTBR-tau243, provides a valuable complement to existing blood tests that measure p-tau217 and amyloid, potentially enabling personalized treatment by helping doctors determine which patients would benefit most from available anti-amyloid or experimental anti-tau therapies.
- With the technology licensed to C2N Diagnostics, this advancement offers a less expensive, less time-consuming, and more widely accessible alternative to PET brain scans, currently the gold standard for staging Alzheimer's, and could significantly improve treatment planning as more stage-specific treatments become available.
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Researchers developing at-home smell test to detect Alzheimer’s
(NewsNation) — Boston neurology researchers have created a test that could allow patients to detect Alzheimer’s at home with a series of sniffs. The test, developed by Mass General Brigham neurology researchers, tests a person's smell recognition and recall in connection to neurodegenerative diseases. Results of the Aromha Brain Health Test found that olfactory dysfunction — a loss of smell or the ability to identify and remember smells — increa…
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