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Blood Biomarkers Reveal Subtle Midlife Cognitive Decline Tied to Alzheimer's Risk

Six percent of 1,350 adults had high blood amyloid and tau, and those participants faced up to four times the risk of rapid decline.

Summary by Medical Xpress
For the first time, researchers found blood biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults who did not have dementia. The study, led by UC San Francisco, also found that the biomarkers, which measure tau and amyloid plaque, were associated with a greater chance of cognitive decline in these participants.

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According to a new study by researchers at the University of California, high P-tau217 levels increase the risk of rapid memory loss by four times.

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The results reinforce the idea that alzhéimer begins decades before clinical diagnosis. The authors consider that earlier detection would allow us to act earlier on modifiable risk factors and better select patients for treatment directed against the disease.The first of the studies analyzed blood samples from 1 350 American adults without dementia and with an average age of 61 years.The researchers measured the levels of several biomarkers link…

Early warning: Already in middle age, a blood test can detect molecular early signs of Alzheimer's disease – long before dementia symptoms become noticeable, as a study now confirms. It also reveals: Already at this time, sufferers show subtle losses in some cognitive achievements. Their mental abilities also decrease faster than with peers without positive biomarkers. A [...] The post Alzheimer reveals itself already in middle age appeared firs…

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Medical Xpress broke the news on Thursday, May 28, 2026.
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