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Bizarre CRISPR enzyme kills cancer cells by shredding their DNA
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Bizarre CRISPR enzyme kills cancer cells by shredding their DNA
Heidi Ledford in Nature: Scientists have exploited a peculiar CRISPR enzyme so that it fights cancer by shredding the DNA in cancer cells, causing them to self-destruct. The enzyme can be programmed to recognize a specific messenger RNA, such as one made by a cancer cell. Once the enzyme finds its partner, it slashes the cell’s genome to pieces. The DNA-shredding approach, reported in two papers in Nature1,2, could provide a way for researchers …
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