Published • loading... • Updated
Why Big Dogs Die Younger Than Small Dogs May Come Down to Jumping Genes
The study of nearly 900 dogs found larger breeds age faster at the molecular level, with epigenetic clocks predicting mortality and highlighting jumping genes.
- Researchers at Arizona State University published findings Thursday in the journal Science identifying a molecular link between body size and aging in dogs, suggesting larger dogs experience accelerated 'epigenetic aging' due to rogue 'jumping genes.'
- DNA methylation normally acts as a 'roadblock' keeping self-replicating 'jumping genes' inactive, but larger dogs lose these protective chemical tags more quickly, allowing genes to damage DNA and trigger inflammation with age.
- Data from 864 dogs in the Dog Aging Project shows large breeds lose 35 percent more LINE1 gene methylation than smaller counterparts, explaining why Irish wolfhounds often live ten years or less.
- Senior study author Noah Snyder-Mackler of Arizona State University developed 'epigenetic clocks' predicting biological age. 'Using our biomarker, this epigenetic clock, big dogs were aging a little bit faster,' he said.
- Future therapies might target transposable elements to extend health spans in both dogs and humans. Snyder-Mackler noted, 'Our work suggests that transposable elements may be a fundamental part of the aging process across mammals.
Insights by Ground AI
23 Articles
23 Articles
The finding could also help to understand some mechanisms of human aging.
·Madrid, Spain
Read Full Article
Dogs of different sizes walk together; study investigated why larger animals tend to age faster and live less. Pexels Dogs of large breeds usually age faster and live less than small ones. A new study published in the journal "Science" found a possible explanation for this difference. Researchers analyzed the DNA of 864 dogs that are part of the "Dog Aging Project", a large research project on canine aging, and identified changes that occur with…
·Rio de Janeiro, Brazil
Read Full Article
The Independent+2 Reposted by 2 other sources
Mystery of why big dogs age faster than small ones finally solved
Researchers analyzed the health of more than 860 dogs
·London, United Kingdom
Read Full Article
Larger breeds lose more quickly some brands that help regulate the genome
·Barcelona, Spain
Read Full ArticleCoverage Details
Total News Sources23
Leaning Left3Leaning Right2Center3Last UpdatedBias Distribution38% Left, 37% Center
Bias Distribution
- 38% of the sources lean Left, 37% of the sources are Center
38% Left
L 38%
C 37%
R 25%
Factuality
To view factuality data please Upgrade to Premium
