Bayer Buys Into KRAS with $1.3bn Kumquat Deal
Bayer will lead late-stage development and commercialization of a KRAS G12D inhibitor targeting mutations in 25% of cancers, with Kumquat receiving up to $1.3 billion in milestone payments.
- Bayer AG announced a $1.3 billion deal to license an early-stage KRAS G12D inhibitor from Kumquat Biosciences, a San Diego biotech, on August 13, 2025.
- The agreement follows Bayer's struggles since its 2018 Monsanto acquisition, which saddled it with high debt and legal challenges, prompting pipeline rebuilding efforts.
- Kumquat will complete a Phase 1a trial of the drug, which targets the prevalent KRAS G12D mutation found in about 37% of pancreatic cancers and several other tumor types.
- Dominik Ruettinger of Bayer expressed enthusiasm about investigating an experimental KRAS G12D inhibitor that targets a critical signaling mechanism involved in cancer progression and cell survival, aligning with the company’s focus on advancing oncology treatments.
- This partnership could accelerate Kumquat's pipeline development, enhance Bayer's precision oncology portfolio, and address unmet needs in cancers lacking effective G12D treatments.
12 Articles
12 Articles
Bayer and Kumquat Biosciences Enter $1.3B Collaboration to Advance Cancer Drug Candidate - USA Herald
Pharmaceutical giant Bayer and clinical-stage biotech company Kumquat Biosciences Inc. today announced an exclusive global license and collaboration agreement, under which Kumquat will receive up to $1.3B to develop and commercialize its pancreatic cancer-focused drug candidate. Under the terms of the agreement, Kumquat will receive funding that includes upfront payments, clinical and commercial milestones, and
Bayer, Kumquat Target KRAS Variant in Up-to-$1.3B+ Cancer Collaboration
Bayer will partner with Kumquat Biosciences to develop Kumquat’s KRAS G12D inhibitor through a collaboration that could generate up to $1.3 billion-plus for the San Diego biotech, while bolstering Bayer’s early precision oncology portfolio with a potential treatment for pancreatic, colorectal, and lung cancer, the companies said Tuesday. The collaboration comes after the FDA last month cleared Kumquat’s investigational new drug (IND) application…
Coverage Details
Bias Distribution
- 50% of the sources are Center
Factuality
To view factuality data please Upgrade to Premium