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Bayer Buys Into KRAS with $1.3bn Kumquat Deal

Bayer will lead late-stage development and commercialization of a KRAS G12D inhibitor targeting mutations in 25% of cancers, with Kumquat receiving up to $1.3 billion in milestone payments.

  • Bayer AG announced a $1.3 billion deal to license an early-stage KRAS G12D inhibitor from Kumquat Biosciences, a San Diego biotech, on August 13, 2025.
  • The agreement follows Bayer's struggles since its 2018 Monsanto acquisition, which saddled it with high debt and legal challenges, prompting pipeline rebuilding efforts.
  • Kumquat will complete a Phase 1a trial of the drug, which targets the prevalent KRAS G12D mutation found in about 37% of pancreatic cancers and several other tumor types.
  • Dominik Ruettinger of Bayer expressed enthusiasm about investigating an experimental KRAS G12D inhibitor that targets a critical signaling mechanism involved in cancer progression and cell survival, aligning with the company’s focus on advancing oncology treatments.
  • This partnership could accelerate Kumquat's pipeline development, enhance Bayer's precision oncology portfolio, and address unmet needs in cancers lacking effective G12D treatments.
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Bloomberg broke the news in United States on Tuesday, August 12, 2025.
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