Holy Peptide Model! BATMAN Outperforms Peptide-TCR Binding Prediction Standard

Holy Peptide Model! BATMAN Outperforms Peptide-TCR Binding Prediction Standard

Data from BATMAN analysis of BATCAVE database could potentially aid in design of high-affinity TCRs with limited off-target cross-reactivity.

BATMAN brings TCR therapy out of the shadows | Cold Spring Harbor Laboratory

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Similarities between cancerous and healthy cells can affect the body’s immune response, causing T cells to attack unintended targets. TCR therapy needs laser focus to prevent friendly fire. New and curiously named AI developed at Cold Spring Harbor Laborator…