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Artesunate Targets GBA, Triggering Apoptosis in Liver Cancer Cells
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BIOENGINEER.ORGArtesunate Targets GBA, Triggering Apoptosis in Liver Cancer Cells
Artesunate, a drug best known for its lifesaving role in malaria treatment, may have a second life as a targeted therapy against hepatocellular carcinoma, the most common primary cancer of the liver. A new study reports that artesunate directly binds to and inhibits glucosylceramidase, or GBA, an enzyme involved in sphingolipid metabolism. By disrupting this metabolic process, the drug triggered a chain of molecular events that damaged mitochond…
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