Mount Sinai Researchers Discover How Alzheimer's Gene Damages Blood Vessels

Mount Sinai researchers discover how Alzheimer's gene damages blood vessels

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

Scientists Discover Mechanism of Brain Blood Vessel Damage

It is well known that Alzheimer's causes progressive decline in memory and thinking. Although cerebrovascular damage has long been recognized, particularly among APOE4 carriers, its mechanisms remained mysterious and it was historically viewed as a secondary consequence of the disease rather than an active driver of its progression.

3D Stem-Cell miBrains Model Complex Neurovascular Pathology in Human Tissue

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

APOE4 Linked to Potentially Reversible Mechanisms of Brain Blood Vessel Damage in Alzheimer’s

Data from two studies using models of brain tissue and aged mice help explain how APOE4, a genetic risk factor for Alzheimer’s disease, damages the brain’s blood vessels and promotes the buildup of abnormal protein. The findings are published in two papers in the journals Cell and Cell Stem Cell. The Cell paper is titled “A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration.” The Cell Stem Cell paper is titled “Chol…

Mount Sinai Researchers Identify How APOE4 Gene Damages Brain Blood Vessels in Alzheimer’s Disease

Two studies using human brain tissue and miBrains, a stem cell-derived human brain model, reveal how APOE4 promotes vascular scarring and abnormal protein buildup, pointing to potential therapeutic targets