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Weight Regain Observed in Patients After Ending Obesity Drug Treatment

HIDALGO COUNTY, TEXAS, JUL 22 – A meta-analysis of 11 trials found patients typically begin regaining weight about eight weeks after stopping anti-obesity medications, with regain continuing for 20 weeks before stabilizing.

  • On Tuesday, the BMC Medicine review showed that data from 11 clinical trials involving nearly 2,500 participants found patients broadly regained weight starting eight weeks after stopping anti-obesity medications, impacting long-term treatment strategies.
  • Reviewing prior findings, researchers led by Xiaoling Cai examined long-term AOM effects and identified a significant research gap, prompting a meta-analysis to address this issue.
  • Their analysis showed weight regain began eight weeks after AOM discontinuation, indicating a pattern, the study found, lasting about 20 weeks before plateauing.
  • The review recommends more long-term studies with extended follow-up to better understand weight regain patterns after anti-obesity medication discontinuation.
  • Considering medication differences, the study suggests these patterns could guide personalized long-term obesity management strategies, emphasizing the need to tailor treatments based on medication type and lifestyle consistency.
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Medical Xpress broke the news in on Monday, July 21, 2025.
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