OLE Identified as a Potential Alzheimer’s Therapy Targeting Microglia
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OLE Identified as a Potential Alzheimer’s Therapy Targeting Microglia
A research collaboration between investigators from the Spanish National Research Council (CSIC), the Miguel Hernández University of Elche (UMH), and the École Polytechnique Fédérale de Lausanne (EPFL) has identified a molecule that may could be a new approach to treating Alzheimer’s disease (AD) by restoring the protective functions of microglia, immune cells found in the brain. The findings, published in Cell Death & Disease, said the molecule…
The study, published in the journal Cell Death and Disease, shows that the compound, called OLE, helps the microglye to surround and contain the beta-amyloid plates, reducing their size and toxicity. In animal models, treatment also improved cognitive performance in memory tests. Alzhéimer is characterized, among other factors, by the accumulation of beta-amyloid plates and by the progressive deterioration of the microglye, the immune cells resp…
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