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UNLV Research Offers Hope for Local Alzheimer's Patients

  • A new study led by the Buck Institute revealed that brain sugar metabolism plays a key role in Alzheimer's disease and dementia.
  • This research emerged from findings that healthy newborns, especially premature babies, have astonishingly high levels of p-tau217, a protein linked to Alzheimer's pathology.
  • Researchers found that boosting the activity of glycogen phosphorylase , an enzyme involved in glycogen breakdown, alleviated tau-induced harm in both fruit fly models and human neurons, and that this enzyme's activity is naturally increased through dietary restriction.
  • Sudipta Bar explained that enhancing GlyP function helps brain cells eliminate harmful reactive oxygen species more effectively, which decreases cellular damage and prolongs the lifespan of flies modeling tauopathy. Kapahi added that this research introduces a promising new avenue for developing therapies targeting Alzheimer's disease and related conditions.
  • The findings suggest understanding and targeting glycogen metabolism could offer novel therapies to combat dementia, potentially explaining why GLP-1 drugs show promise against this disease.
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Medical Xpress broke the news in on Monday, June 30, 2025.
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