UNLV Research Offers Hope for Local Alzheimer's Patients
- A new study led by the Buck Institute revealed that brain sugar metabolism plays a key role in Alzheimer's disease and dementia.
- This research emerged from findings that healthy newborns, especially premature babies, have astonishingly high levels of p-tau217, a protein linked to Alzheimer's pathology.
- Researchers found that boosting the activity of glycogen phosphorylase , an enzyme involved in glycogen breakdown, alleviated tau-induced harm in both fruit fly models and human neurons, and that this enzyme's activity is naturally increased through dietary restriction.
- Sudipta Bar explained that enhancing GlyP function helps brain cells eliminate harmful reactive oxygen species more effectively, which decreases cellular damage and prolongs the lifespan of flies modeling tauopathy. Kapahi added that this research introduces a promising new avenue for developing therapies targeting Alzheimer's disease and related conditions.
- The findings suggest understanding and targeting glycogen metabolism could offer novel therapies to combat dementia, potentially explaining why GLP-1 drugs show promise against this disease.
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UNLV research offers hope for local Alzheimer's patients
LAS VEGAS (KLAS) -- The 2025 Alzheimer’s Pipeline Report, released by the Kirk Kerkorian School of Medicine at UNLV, reveals dozens of promising drug trials that could bring hope to millions of families. The research happening in the Las Vegas valley is giving two local women hope. “As someone who has lived with this disease all my life, I can’t tell you how excited my heart feels when I see the efforts of all these scientists right here,” said …


What the Brains of Centenarians Reveal
(MedPage Today) -- Most people who survived to age 100 and beyond had amyloid-beta accumulation and, when present, it was tied to cognitive performance, an autopsy study showed. In a study of 95 centenarians, more than half (56%) had a low amyloid...
Babies have more of this Alzheimer’s-linked protein than dementia patients – study raises hope for future treatments
FamVeld/Shutterstock.comA protein long blamed for the brain damage seen in Alzheimer’s disease has now been found in astonishingly high levels in healthy newborn babies, challenging decades of medical dogma. The discovery could transform our understanding of both brain development and Alzheimer’s disease itself. The protein, called p-tau217, has been viewed as a hallmark of neurodegeneration – yet a new study reveals it’s even more abundant in t…
Scientists just found a sugar switch that protects your brain from Alzheimer's
Scientists have uncovered a surprising sugar-related mechanism inside brain cells that could transform how we fight Alzheimer’s and other dementias. It turns out neurons don’t just store sugar for fuel—they reroute it to power antioxidant defenses, but only if an enzyme called GlyP is active. When this sugar-clearing system is blocked, toxic tau protein builds up and accelerates brain degeneration.
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