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Early-Stage Alzheimer Disease: Getting Trial-Ready
4 Articles
4 Articles
Early-stage Alzheimer disease: getting trial-ready
Slowing the progression of Alzheimer disease (AD) might be the greatest unmet medical need of our time. Although one AD therapeutic has received a controversial accelerated approval from the FDA, more effective and accessible therapies are urgently needed. Consensus is growing that for meaningful disease modification in AD, therapeutic intervention must be initiated at very early (preclinical or prodromal) stages of the disease. Although the met…
Diagnosing and Staging Alzheimer Disease in Frontline Care Settings
Panelists discuss how frontline physicians evaluate patients for Alzheimer by balancing observable signs, cognitive testing, and advanced imaging, recognizing the disease’s nuanced progression and individual variability, which underscores the importance of personalized assessments for early diagnosis and tailored care.
Alzheimer's disease can start much earlier than we think, with sensory disorders often ignored. Recent studies show that changes in the perception of taste, sounds or balance could precede memory loss. These early signals are usually attributed to natural aging, while they may reveal a latent cognitive disorder. Therefore, diagnostic windows should widen and accompanying measures, as proposed by France Alzheimer and related diseases.
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