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Alumis Stock Nearly Doubles on Psoriasis Drug Trial, FDA Plans

Envudeucitinib achieved high skin clearance rates, with 74% reaching 75% lesion clearance, prompting Alumis to plan U.S. approval and a $175 million share offering.

  • On Jan 6, 2026, Alumis said envudeucitinib met all endpoints in two Phase 3 trials and plans U.S. approval later this year.
  • By the numbers, envudeucitinib helped 74% achieve PASI75 and around 65% reach PASI90 at week 24, targeting IL‑23 and IL‑17 pathways.
  • Comparisons to J&J and Takeda show Alumis' envudeucitinib posting similar results and potentially being 'class‑leading' for TYK2 inhibition, competing with Bristol Myers Squibb's Sotyktu, which earned $126 million in the first nine months of 2025.
  • Trading showed a dramatic market response, with trading volume 64.1 million shares and 3,077% above three‑month average, shares up nearly 82%, and Alumis announcing a $175.0 million offering of common stock.
  • The focus is now on New Drug Application timing and competitive dynamics as envudeucitinib is tested in Crohn's disease and systemic lupus erythematosus with phase 2b results due in the third quarter of 2026.
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biopharmadive.com broke the news in on Tuesday, January 6, 2026.
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