AI-Designed DNA Repair Templates Improve Gene Editing Precision

AI-powered CRISPR tool enhances precision in gene editing

Researchers from the University of Zurich have developed an AI-driven gene editing method that improves DNA repair predictions, enabling more accurate and safer genome modifications Scientists at the University of Zurich have developed an advanced AI tool, named Pythia, that significantly boosts the precision of CRISPR gene editing. By accurately predicting how DNA will repair itself after being cut, Pythia addresses one of the biggest challenge…

AI-Designed DNA Repair Templates Improve Gene Editing Precision

Targeted DNA editing by CRISPR technology has great potential for applications in biotechnology and gene therapy. However, precise gene editing remains a challenge largely due to insufficient control of the DNA repair process. While mechanisms exist to accurately repair double-stranded breaks, DNA end joining repair can occasionally lead to genetic errors.   In a new study published in Nature Biotechnology titled, “Precise, predictable genome in…

AI Meets CRISPR for Precise Gene Editing

12.08.2025 - A research team headed by the University of Zurich has developed a powerful new method to precisely edit DNA by combining cutting-edge genetic engineering with artificial intelligence. This technique opens the door to more accurate modeling of human diseases and lays the groundwork for next-generation gene therapies.