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AI-Designed COVID Vaccine Passes First Human Trial

The needle-free DNA shot was safe in 39 volunteers and triggered immune responses to SARS-CoV-2, SARS and related bat viruses.

  • Researchers at the University of Cambridge and DIOSynVax developed an AI-designed 'super-antigen' vaccine offering protection against entire families of viruses rather than just specific strains.
  • Artificial intelligence analyzed genetic codes from various coronaviruses to identify essential, unchanging elements across virus families, creating a 'fundamentally new' approach that future-proofs against mutations.
  • A phase I trial in Cambridge and Southampton involving 49 healthy volunteers aged 18 to 50 confirmed the vaccine is safe and triggered immune responses against SARS-CoV-2, SARS, and related bat viruses.
  • More than 200 individuals will be recruited for a forthcoming phase II study, with Professor Jonathan Heeney calling the technology a 'game changer' for vaccine development.
  • Scientists are now exploring applications for other virus families, including Ebola and bird flu, aiming to prevent pandemics before they start and potentially save millions of lives.
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They designed the first vaccine with the help of artificial intelligence.

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The Independent broke the news in London, United Kingdom on Thursday, June 4, 2026.
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