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A Woman With Headache, Fatigue, and Aphasia

Summary by JAMA Network
A woman with no significant medical history had 3 days of headache, fatigue, and expressive aphasia; laboratory testing showed microangiopathic hemolytic anemia, increasing schistocytes on serial blood smears, diminished ADAMTS13 activity, and a high inhibitor titer. What is the diagnosis and what would you do next?

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JAMA NetworkJAMA Network

A Woman With Headache, Fatigue, and Aphasia

A woman with no significant medical history had 3 days of headache, fatigue, and expressive aphasia; laboratory testing showed microangiopathic hemolytic anemia, increasing schistocytes on serial blood smears, diminished ADAMTS13 activity, and a high inhibitor titer. What is the diagnosis and what would you do next?

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JAMA Network broke the news in on Tuesday, August 12, 2025.
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