US EditionMolecular Switch Links Early-Life Stimulation to Lasting Memory Changes
Activating the transcription factor AP-1 in mice links early enriched environments to stronger memory by regulating gene networks and neuronal plasticity, study shows.
5 Articles
5 Articles
Molecular switch links early-life stimulation to lasting memory changes
Researchers have identified a molecular mechanism that helps explain why growing up in a stimulating environment enhances memory. In contrast, a lack of stimulation can impair it. The team from the Institute for Neurosciences (IN), a joint research center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), was led by researcher Ángel Barco.
Molecular switch links early life stimulation to lasting memory changes
Researchers have identified a molecular mechanism that helps explain why growing up in a stimulating environment enhances memory. In contrast, a lack of stimulation can impair it. The team from the Institute for Neurosciences (IN), a joint research center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), was led […] The post Molecular switch links early life stimulation to lasting memory changes appe…
The study, carried out in mice and published in Nature Communications, shows that the environment during childhood and adolescence leaves a stable footprint in the brain by activating or deactivating the same transcription factor, AP-1, which regulates the expression of genes involved in neuronal plasticity and learning. This finding identifies a molecular mediator capable of translating vital experiences into persistent changes in cognitive fun…
Early-Life Stimulation Switches On a Molecular Code for Memory
New research shows that childhood environments shape lifelong memory through a single molecular switch that controls learning-related gene activity. In animal models, enriched early experiences activated this switch, strengthening neural circuits involved in memory and cognition, while deprived environments suppressed it.
A team from the Institute of Neurosciences (IN), center of the Higher Council of Scientific Research (CSIC) and the Miguel Hernández University (UMH) of Elche, has discovered a molecular mechanism that helps explain why growing up in a stimulating environment improves memory, while the lack of stimuli can deteriorate it. The study, carried out in mice and published in Nature Communications, shows that the environment during childhood and adolesc…
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