Study Explains Why Cancer Immunity Declines Faster in Males
The findings suggest male sex hormones suppress thymic function, and a short-term intervention in mice restored naive CD8 T cells and improved checkpoint blockade response.
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5 Articles
Study explains why cancer immunity declines faster in males
Lutz Menzel, PhD, formerly of the Department of Radiation Oncology within the Mass General Brigham Cancer Institute, and Tim Padera, PhD, currently of the Mass General Brigham Cancer Institute, are the lead and senior authors of a paper published in Nature Aging, "Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age."
Age and sex shape cancer immunity, mouse experiments and human data suggest
A new study published in Nature Aging combines mouse experiments and human data sets to explore how biological sex and aging shape cancer immunity, with implications for immunotherapy responses. Lutz Menzel, Ph.D., formerly of the Department of Radiation Oncology within the Mass General Brigham Cancer Institute, is the lead author, and Tim Padera, Ph.D., of the Mass General Brigham Cancer Institute, is the senior author. The paper is titled "Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age."
Immune aging does not advance the same in both sexes. A team from the Brigham Oncological Institute in Massachusetts has described why males lose the ability to respond to tumors before and has placed the adult thymus as a possible therapeutic lever. The work, led by Lutz Menzel and Tim Padera, is published in Nature Aging and combines models of melanoma in mouse with data from human patients. The question that has been dragging oncological immu…
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Scienmag: Latest Science and Health NewsA Shrinking Thymus May Blunt Cancer Immunity in Middle-Aged Men
New research in Nature Aging shows that accelerated loss of naive CD8+ T cells in middle-aged male mice shrinks lymph nodes and undermines cancer antigen recognition, but restoring thymic output replenishes the immune reservoir and improves immunotherapy responses.
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