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A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial
- A Nature Medicine paper published on Monday by Erritzoe and colleagues reported that a single intravenous DMT dose rapidly reduced depressive symptoms in 34 adults with major depressive disorder.
- Many people with major depressive disorder do not respond adequately to selective serotonin reuptake inhibitors or tolerate side effects, while dimethyltryptamine's brief intravenous effects could enable shorter therapy sessions.
- The randomized design assigned 17 people to each arm, administering intravenous infusions over about 10 minutes, and by two weeks DMT recipients showed greater depression score reductions with 47% meeting remission by three months.
- In terms of safety, researchers reported side-effect rates of 64.7% and 62.5% with DMT versus 23.5% placebo, noting study limitations including small sample and 88.2% white participants.
- Regulatory reviews and larger phase 3 trials will determine clinical adoption, with Erritzoe's team testing HLP004 and others like AtaiBeckley and 5‑MeO‑DMT advancing in parallel.
17 Articles
17 Articles
Preliminary, the results add to a growing body of evidence that psychedelic drugs, when combined with psychotherapy, can help alleviate depression in millions of people worldwide.
A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial
Major depressive disorder (MDD) is a leading cause of disability worldwide, yet many patients have inadequate responses to current treatments. Dimethyltryptamine (DMT), a serotonergic psychedelic with rapid onset and short duration, shows promise as a potential antidepressant (AD), although clinical evidence in MDD remains limited. We conducted a phase IIa, double-blind, placebo-controlled, randomized clinical trial to evaluate the efficacy and …
A single dose of dimethyltryptamine - active substance of ayahuasca - and administered with psychological support quickly reduced depressive symptoms.
Psychedelic drug relieved severe depression for months, study finds
A single dose of a particular psychedelic drug has been found to rapidly reduce symptoms of depression, suggesting a new form of mental health treatment.A UK clinical trial, the results of which were published in the journal Nature Medicine this morning, showed that a dose of the drug dimethyltryptamine (DMT), given with psychological support, rapidly reduced depressive symptoms in 34 adults with major depressive disorder.Major depressive disor…
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der Standard DEA small pilot study gives hope: Already a single intravenous dose of DMT showed immediate antidepressant effects. But further investigations are necessary
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