A new targeted approach could protect neurons against degeneration

A new targeted approach could protect neurons against degeneration

Neurodegenerative conditions such as Parkinson's disease and Alzheimer's involve progressive neuronal loss due to disease-induced damage. An enzyme known as dual leucine-zipper kinase (DLK) plays a key role in this process, telling neurons that are damaged or unhealthy when they should cut their losses and self-destruct. Hence, sparing neurons from DLK is an attractive therapeutic strategy that could slow disease progression.