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A polyene macrolide targeting phospholipids in the fungal cell membrane

Summary by Nature
The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery of antifungals with unique modes of action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by the high-frequency rediscovery of known compounds and the lack of new antifungal targets2. Here we report the discovery of a polyene antifungal antibiotic, mandimycin, …

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A polyene macrolide targeting phospholipids in the fungal cell membrane

The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery of antifungals with unique modes of action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by the high-frequency rediscovery of known compounds and the lack of new antifungal targets2. Here we report the discovery of a polyene antifungal antibiotic, mandimycin, …

·United Kingdom
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A new antifungal drug works in a surprising way

Mandimycin, which targets a different essential fungi cell resource than other antifungal drugs, should harm other cell types as collateral — but doesn’t.

·United States
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ecotopical.comecotopical.com

Use of antifungals in agriculture may increase resistance in an infectious yeast

Genomic changes in the infectious yeast Candida tropicalis may play a role in its resistance to antifungals, according to a study published in PLOS Biology. The work, led by Guanghua Huang at Fudan University, China, and colleagues, shows that these genomic changes can be brought on by a common antifungal, TBZ. The study demonstrates that the use of TBZ in agriculture may contribute to the increasing problem of antifungal resistance.

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Science News broke the news in United States on Tuesday, April 1, 2025.
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