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FOXP4 Gene Variants Reveal New Genetic Link to Long COVID Risk
- On May 23, 2025, a collaborative team of researchers from Karolinska Institutet in Sweden and Finland’s Institute for Molecular Medicine released a meta-analysis demonstrating a connection between FOXP4 gene variants and the likelihood of developing long COVID, based on data collected from 19 countries.
- This study arose from efforts by the COVID-19 Host Genetics Initiative to identify genetic factors contributing to long COVID, defined by symptoms lasting over two months after recovery.
- Researchers analyzed data from nearly 16,000 long COVID cases and 1.9 million controls, finding the rs9367106-C variant near FOXP4 increases risk and is more common in East Asians than Europeans.
- Lead author Hugo Zeberg explained that reduced lung capacity is an important factor in the development of long COVID, while also highlighting that the gene variant represents only one element within a broader and more complex risk landscape.
- The study highlights lung biology’s importance in long COVID susceptibility and supports vaccination’s protective role against persistent symptoms.
11 Articles
11 Articles
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies
The global evidence on the risk of symptoms of Long Covid in general populations infected with SARS-CoV-2 compared to uninfected comparator/control populations remains unknown. We conducted a systematic literature search using multiple electronic databases from January 1, 2022, to August 1, 2024. Included studies had ≥100 people with confirmed or self-reported COVID-19 at ≥28 days following infection onset, and an uninfected comparator/control g…
FOXP4 gene variants reveal new genetic link to long COVID risk
Researchers have identified genetic variants in the FOXP4 gene that significantly increase the risk of developing long COVID, independently of COVID-19 severity. The study also reveals that ancestry, smoking, and other factors contribute to the complex genetics of long COVID.
Gene variant linked to higher risk of long COVID symptoms
An international team of researchers has found a genetic link to long-term symptoms after COVID-19. The identified gene variant is located close to the FOXP4 gene, which is known to affect lung function. The study, published in Nature Genetics, was led by researchers at Karolinska Institutet in Sweden and the Institute for Molecular Medicine in Finland.
New Research Links IL-6 Levels and Genetic Variant to Long Covid Risk
Researchers identified immune system markers linked to long Covid, offering hope for better diagnosis and targeted treatment options. The post New Research Links IL-6 Levels and Genetic Variant to Long Covid Risk appeared first on Psychreg.
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