Development of a Broad-Spectrum Subunit Vaccine Against H9N2 Avian Influenza Using HA Stem Domain Scaffold and Snoopligase System

Development of a broad-spectrum subunit vaccine against H9N2 avian influenza using HA stem domain scaffold and snoopligase system

H9N2 avian influenza virus (AIV) is a globally prevalent pathogen that causes economic losses in poultry and poses zoonotic threats. Due to antigenic drift and shift, traditional inactivated vaccines often show reduced efficacy. This study presents a novel subunit vaccine based on a conserved HA6 scaffold derived from the hemagglutinin stem domain and coupled with a fusion peptide epitope (fPE) via Snoopligase-mediated ligation. The HA6 protein …

A Dangerous Gamble: The U.S. Abandons Bird Flu Vaccine Preparedness

The virus has not yet evolved to spread efficiently between people. Excellent vaccine technology exists, but the government has just withdrawn funding for the development of a bird flu vaccine. Every day that passes without investment and planning increases the odds that we will be unprepared for the next pandemic.

Guyana boosts influenza preparedness through surveillance, laboratory and vaccine planning efforts

– Guyana has made significant progress in recent years in detecting, monitoring and responding to influenza and other respiratory threats. To increase the represtentativeness of the system and improve the timely detections of increased influenza activity, Guyana increased the number of sentinel surveillance sites from four to twelve in less than two years. In parallel, Guyana began weekly reporting of surveillance data to the Pan American Health…