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A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression
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A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression
Using CRISPR/Cas9-mediated genome engineering in primary human fetal liver-derived HSCs and xenotransplantation in mice, researchers modeled GATA2-deficient myelodysplastic syndrome with acquired STAG2 loss to investigate disease initiation and progression. [Blood Advances] Abstract
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